In this case, you can solve the problem by installing the VBoxDrv.inf manually. Then, the VM won’t start and the error E_FAIL (0x80004005) occurs. However, it’s possible that due to some permission issues, the installation of this crucial driver isn’t completed during the initial installation. VBoxDrv.inf is a driver used for VirtualBox. Then, restart VirtualBox and it will work just fine. To solve this problem, you just need to make a copy of the "VM_NAME.xml-prev" file and rename the copy to "VM_NAME.xml". However, when the E_FAIL (0x80004005) error occurs, it seems that VirtualBox simply just couldn't find "VM_NAME.xml" because this file technically doesn’t exist. When VirtualBox starts a VM, it needs to find an XML file.
When the E_FAIL (0x80004005) error occurs, please navigate to the folder " C:\Users\COMPUTER_NAME\.VirtualBox\Machines\VM_NAME" and check whether there are the following two files: The error details, the component, and the interface may be various, but the “ Failed to open a session for the virtual machine xx.” message and “Result Code: E_FAIL (0x80004005)” will not change. However, some people report that they have encountered the VirtualBox E_FAIL (0x80004005) error when starting a VM. It supports the creation and management of guest virtual machines running Windows, Linux, BSD, OS/2, Solaris, Haiku, and OSx86, as well as limited virtualization of macOS guests on Apple hardware. It can be installed on Microsoft Windows, macOS, Linux, Solaris, and OpenSolaris.
VirtualBox is an open-source type-2 hypervisor for x86 virtualization.
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